Radiation dose-volume effects of optic nerves and chiasm.

نویسندگان

  • Charles Mayo
  • Mary K Martel
  • Lawrence B Marks
  • John Flickinger
  • Jiho Nam
  • John Kirkpatrick
چکیده

Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.

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عنوان ژورنال:
  • International journal of radiation oncology, biology, physics

دوره 76 3 Suppl  شماره 

صفحات  -

تاریخ انتشار 2010